Programul 16-imilor (14/21 februarie 2019):
Viktoria Plzen – Dinamo Zagreb
Club Brugge – Salzburg
Rapid Viena – Internazionale Milano
Slavia Praga – Genk
Krasnodar – Leverkusen
Zurich – Napoli
Malmo – Chelsea
Sahtior Donetk – Eintracht Frankfurt
Celtic – Valencia
Rennes – Betis Sevilla
Olympiacos – Dynamo Kiev
Lazio – Sevilla
Fenerbahce – Zenit
Sporting Lisabona – Villarreal
BATE Borisov – Arsenal
Galatasaray – Benfica
Cele 32 de echipe ajunse in aceasta faza a competitiei au fost impartite in doua urne valorice.
Urna capilor de serie
Leverkusen, Salzburg, Zenit, Dinamo Zagreb, Arsenal, Betis, Villarreal, Frankfurt, Genk, Sevilla, Dynamo Kiev, Chelsea, Napoli, Valencia, Internazionale, Benfica.
A doua urna valorica
Zurich, Celtic, Slavia Praga, Fenerbahce, Sporting, Olympiacos, Rapid Viena, Lazio, Malmo, Krasnodar, Rennes, BATE, Plzen, Club Brugge, Sahtior Donetk, Galatasaray.
